HORDB

ID: hor001870
Uniprot ID: P01280(1-27)
Protein name: Secretin
Gene name: SCT
Organism: Gallus gallus (Chicken)
Family: Glucagon family
Source: animal
Expression: small intestine
Disease: NA
Comments: NA
Taxonomy: Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0046659 digestive hormone activity
GO BP: GO:0002024 diet induced thermogenesis; GO:0007165 signal transduction; GO:0009992 intracellular water homeostasis; GO:0021766 hippocampus development; GO:0031667 response to nutrient levels; GO:0032098 regulation of appetite; GO:0048167 regulation of synaptic plasticity; GO:0050996 positive regulation of lipid catabolic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Function: Controls gastrointestinal activity
Mechanism: May be autocrine / paracrine factors involved in the regulation of testicular function
Cross BBB: NO
Target: SCTR
Target Unid: D2CP28
IC50: NA
EC50: 0.31nM
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01280-F1.pdb

hor001870_AF2.pdb

hor001870_ESM.pdb

Mass:	359448	Formula:	C136H213N39O42S2
Absent amino acids:	CPW	Common amino acids:	QS
pI:	9.26	Basic residues:	4
Polar residues:	9	Hydrophobic residues:	7
Hydrophobicity:	-65.56	Boman Index:	-5587
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	57.78
Instability Index:	1696.3	Extinction Coefficient cystines:	1490
Absorbance 280nm:	57.31

PubMed ID: 7460928
Title: Isolation and characterization of chicken secretin.
PubMed ID: 21939730
Title: Characterization of chicken secretin (SCT) and secretin receptor (SCTR) genes: a novel secretin-like peptide (SCT-LP) and secretin encoded in a single gene.