General Information

  • ID:  hor001870
  • Uniprot ID:  P01280
  • Protein name:  Secretin
  • Gene name:  SCT
  • Organism:  Gallus gallus (Chicken)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  small intestine
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gallus (genus), Phasianinae (subfamily), Phasianidae (family), Galliformes (order), Galloanserae (superorder), Neognathae (infraclass), Aves (class), Coelurosauria, Theropoda, Saurischia, Dinosauria, Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0046659 digestive hormone activity
  • GO BP:  GO:0002024 diet induced thermogenesis; GO:0007165 signal transduction; GO:0009992 intracellular water homeostasis; GO:0021766 hippocampus development; GO:0031667 response to nutrient levels; GO:0032098 regulation of appetite; GO:0048167 regulation of synaptic plasticity; GO:0050996 positive regulation of lipid catabolic process
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  HSDGLFTSEYSKMRGNAQVQKFIQNLM
  • Length:  27(1-27)
  • Propeptide:  HSDGLFTSEYSKMRGNAQVQKFIQNLM
  • Signal peptide:  NA
  • Modification:  T27 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Controls gastrointestinal activity
  • Mechanism:  May be autocrine / paracrine factors involved in the regulation of testicular function
  • Cross BBB:  NO
  • Target:  SCTR
  • Target Unid:  D2CP28
  • IC50: NA
  • EC50: 0.31nM
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01280-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01280-F1.pdbhor001870_AF2.pdbhor001870_ESM.pdb

Physical Information

Mass: 359448 Formula: C136H213N39O42S2
Absent amino acids: CPW Common amino acids: QS
pI: 9.26 Basic residues: 4
Polar residues: 9 Hydrophobic residues: 7
Hydrophobicity: -65.56 Boman Index: -5587
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 57.78
Instability Index: 1696.3 Extinction Coefficient cystines: 1490
Absorbance 280nm: 57.31

Literature

  • PubMed ID:  7460928
  • Title:  Isolation and characterization of chicken secretin.
  • PubMed ID:  21939730
  • Title:  Characterization of chicken secretin (SCT) and secretin receptor (SCTR) genes: a novel secretin-like peptide (SCT-LP) and secretin encoded in a single gene.